L-Serine Research by Brain Chemistry Labs
Additional Resources on L-Serine Research by Brain Chemistry Labs
FDA Approves Phases II and IIa Clinical Trial of L-Serine
See links to FDA-approved Phase II clinical trial of L-serine for ALS patients and Phase IIa clinical trial of L-serine for early stage Alzheimer's patients
L-Serine Safe for ALS Patients.
Brain Chemistry Labs completed a Phase I ALS trial (to demonstrate the safety of the naturally occurring amino acid, L-serine, in humans) that showed encouraging signs of slowing disease progression among enrolled patients.
L-Serine's Potential for ALS Patients.
Ogimi Village is Renowned for its Aging Population. Dr. Paul Cox, with his colleagues at Brain Chemistry Labs, sought to determine if the L-serine content of their diet could account for their neurological health.
Additional L-Serine Research Links:
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Mechanisms of L-Serine Neuroprotection in vitro Includes ER Proteostasis Regulation
Dunlop RA, Powell J, Guillemin GJ, Cox PA
Neurotoxicity Research. 2018 Jan 1;33(1):123-32. -
L-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI)
Dunlop RA, Powell JT, Metcalf JS, Guillemin GJ, Cox PA
Neurotoxicity Research. 2018 Jan 1;33(1):113-22. -
L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential
Metcalf JS, Dunlop RA, Powell JT, Banack SA, Cox PA
Neurotoxicity Research. 2017 Sep 19:1-9. -
Studies of Environmental Risk Factors in Amyotrophic Lateral Sclerosis (ALS) and a Phase I Clinical Trial of L-serine
Bradley WG, Miller RX, Levine TD, Stommel EW, Cox PA
Neurotoxicity Research. 2018 Jan 1;33(1):192-8 -
Traditional Food Items in Ogimi, Okinawa: L-Serine Content and the Potential for Neuroprotection
Cox PA, Metcalf JS
Current Nutrition Reports. 2017 Mar 1;6(1):24-31. -
Phase I clinical trial of safety of L-serine for ALS patients
Levine TD, Miller RG, Bradley WG, Moore DH, Saperstein DS, Flynn LE, Katz JS, Forshew DA, Metcalf JS, Banack SA, Cox PA
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2017 Jan 2;18(1-2):107-11.
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